MR-Image Guided Focused Ultrasound for Treatment of Liver and Renal Cancer R01CA121163
The long-term goal of this collaboration between the NCIGT and researchers at Stanford University is to develop a minimally invasive treatment for cancers in the upper abdomen, including renal cell carcinoma and primary and metastatic tumors in the liver. The group at Stanford has been investigating a novel MR temperature imaging method based on single phase maps that does not require image subtractions. They have been working on methods to combine data from the elements of MRI phased array coils. Through this collaboration, the NCIGT leverages Stanford’s expertise in liver and kidney MR-guided focused ultrasound surgery (MRgFUS), while the Stanford group leverages the NCIGT's expertise in uterine fibroid, prostate, bone, and brain MRgFUS. The group in Stanford has developed practical solutions to the challenges posed by motion and the use of phased array MR coils with MR temperature imaging. It has shared these solutions with the FUS Core for its ongoing prostate MRgFUS trial. Stanford has used in vivo animal data that was obtained by the FUS Core in its animal trial of a prostate MRgFUS system to test a "referenceless" MR temperature imaging approach with data obtained with phased array MR coils.
Publications
- Grissom, W., K. Butts-Pauly, Lustig M, Rieke V, Pauly J, McDannold N, Regularized referenceless temperature estimation is PRF-shift MR thermometry. ISBI 2009.
- Grissom W, Rieke V, Pauly J, McDannold N, Butts Pauly, K, Regularized Multicoil MR Thermometry, ISMRM 2009.