Ferenc Jolesz First Monday Research Seminars
The Department of Radiology holds a monthly Ferenc Jolesz Seminar series presented by Harvard Medical School investigators, as well as speakers from other institutions, on a wide range of topics related to image-guided therapy. These seminars honor the late Dr. Ferenc Jolesz who founded the multidisciplinary image-guided therapy program at Brigham and Women’s Hospital and is widely known as a founding father of the field of image-guided therapy.
Upcoming Seminars
Jeremy Wolfe, PhD: Seeing more than we think we see. Missing more than we want to miss.
DATE: Monday, May 6th, 2024
TIME: 12:15pm-1:15pm
LOCATION: Anesthesia Lecture Hall and via Zoom – https://partners.zoom.us/j/84073649536
Located at 45 Francis Street entrance on the L1 level. Enter through the sliding doors at the 45 Francis Street entrance, go straight through the lobby. You will be on the 2nd floor. Take a left onto the 2nd floor hallway called “the Pike”. Continue straight until you see the Mary Horrigan Connors elevators on your right. Take these elevators to level L1. When you exit the elevators, look directly to your left. There will be a set of double doors with a sign for the Anesthesia Department. Enter through these double doors and continue straight until you reach a wall. Make a left and the room will be straight ahead.
Jeremy Wolfe, PhD
Professor of Ophthalmology and Radiology
Harvard Medical School
Your powers of vision and visual cognition are quite amazing. For example, an expert can look at a mammogram for a quarter of a second and beat chance at knowing whether the patient will develop cancer three years from now. At the same time, the same expert mammographer can miss a clearly visible mass under standard viewing conditions. Or consider the fact that you can look at at your resumé for hours and still fail to notice an embarrassing typo (Did you notice the doubled word in the previous sentence?). How can both things be true at the same time? I will illustrate some of your capabilities and some of your limitations and I will attempt to reconcile these competing facts. We will discuss how radiology and radiology research might respond to these bugs and features of the human operating system.
Jeremy Wolfe, PhD, is Professor of Ophthalmology and Professor of Radiology at Harvard Medical School and Director of the Visual Attention Lab at Brigham and Women’s Hospital in the Department of Surgery. Wolfe received an AB in Psychology in 1977 from Princeton and his PhD in Psychology in 1981 from MIT. His research focuses on visual search and visual attention with a particular interest in socially important search tasks in areas such as medical image perception (e.g. cancer screening), security (e.g. baggage screening), and intelligence. This research has been funded at different times since 1982 by NIH (NEI, NIMH, NCI), NSF, AFOSR (Air Force), ONR (Navy), ARO (Army), Homeland Security, and the Nat. Geospatial Agency as well as by IBM, Google, Toshiba, Hewlett-Packard, & GE. Wolfe taught Introductory Psychology and other courses for 25 years, mostly at MIT. He has served as Past President or Chair of the Federation of Associations in Behavioral and Brain Sciences (FABBS), the Psychonomic Soc, APA Division 3, Eastern Psychological Assoc, NAS Panel on Soldier Systems. He has served on the Governing Boards of the Vision Sciences Society, APA Div 1 and 6. Wolfe was Founding Editor-in-Chief of Cognitive Research: Principles and Implications (CRPI), the newest Psychonomic Society journal, and Past-Editor of Attention, Perception, and Psychophysics. Wolfe also serves on the Board of the North American Board of the Union for Reform Judaism. He was elected to American Academy of Arts and Sciences in 2019.
Fides Schwartz, MD: Photon-counting CT – What is it and what do we do with it?
Fides Schwartz, MD Research Associate in Radiology Harvard Medical School Lead Investigator Center of Advanced CT Translation and Innovation (CACTI) Brigham and Women’s Hospital Abstract Photon-counting Computed Tomography (PCCT) has emerged as a transformative technology…
SHARATH BHAGAVATULA, MD: TRANSLATIONAL RESEARCH IN INTERVENTIONAL RADIOLOGY: EARLY EXPERIENCE IN TRANSLATING AN IMPLANTABLE MICRODEVICE TECHNOLOGY FOR PERSONALIZED DRUG RESPONSE ASSESSMENT
Sharath Bhagavatula, MD Assistant Professor of Radiology Abdominal Imaging and Intervention Brigham and Women’s Hospital Harvard Medical School Abstract Novel image-guided interventional methods have the potential to significantly improve cancer diagnosis and treatment, but the…
Stephan Maier, MD, PhD: The Quest for Quantitative Parameters in Magnetic Resonance Imaging
Stephan Maier, MD, PhD Associate Professor Department of Radiology, Brigham and Women’s Hospital Harvard Medical School Abstract Numerous quantitative parameters, such as spatial dimensions, volume, nuclear magnetic resonance relaxation, velocity, and diffusion can be measured…
Sila Kurugol, PhD: Advancements in Abdominal MRI: Enhancing Quantitative Imaging with Innovations in Diffusion-Weighted and Dynamic Contrast-Enhanced MRI
Sila Kurugol, PhD Assistant Professor of Radiology Director of Quantitative Intelligent Imaging Lab Department of Radiology, Boston Children’s Hospital and Harvard Medical Abstract The presentation will highlight recent advancements in two key MRI sequences for…
Bingxin Zhao, PhD: Multi-organ Imaging Genomics: New Resources and Findings
Bingxin Zhao, PhD Assistant Professor Department of Statistics and Data Science University of Pennsylvania Abstract Large-scale imaging genetics data are opening new directions for a multi-organ understanding of human health. In this presentation, we will…
Peter Caravan, PhD: The Future of MR Contrast Agents: Molecular MR and Gadolinium-free Contrast
Peter Caravan, PhD Co-Director, Institute for Innovation in Imaging (i3) Department of Radiology Massachusetts General Hospital Professor of Radiology Harvard Medical School Abstract Contrast enhanced MR utilizes small, hydrophilic gadolinium chelates that freely distribute in…
Nadya Shusharina, PhD: Harnessing DW-MRI to Identify Direction of the Microscopic Tumor Spread
Nadya Shusharina, PhD Instructor in Radiation Oncology Massachusetts General Hospital Abstract I will present our ongoing work to develop a microscopic tumor spread model for soft tissue sarcoma (STS) and glioma that is based on pre-treatment…
Lucila Ohno-Machado, MD, MBA, PhD: Data Science to Promote Precision Medicine for All
Lucila Ohno-Machado, MD, MBA, PhD Waldemar von Zedtwitz Professor of Medicine and Biomedical Informatics and Data Science Deputy Dean for Biomedical Informatics, Yale School of Medicine Chair, Section of Biomedical Informatics and Data Science Abstract…
Sanghoon Kim, MD, MSc: BWH 3T MRS 2HG Optimization Progress Report
Sanghoon Kim, MD, MSc Research Fellow (T32) Department of Radiology Brigham and Women’s Hospital Abstract 2HG is the specific biomarker for the IDH mutation in gliomas. To get the correct spectrum analysis, precise basis set…
Susie Y. Huang, MD, PhD: Characterizing Tissue Microstructure in the Living Human Brain Using High-Gradient Diffusion MRI
Susie Huang, MD, PhD Associate Professor, HMS Radiologist, MGH Abstract Less is known about the structure-function relationship in the human brain than in any other organ system. The challenge of studying brain structure is that…
Zhou Lan, PhD: Recent Statistical Methods for Diffusion MRI
Zhou Lan, PhD Instructor in Medicine, HMS Biostatistics Investigator, BWH Abstract Diffusion MRI is a popular imaging technique to investigate the tissue microstructure. The diffusion MRI data has been routinely used for various medical applications.…
Denis Rancourt Peng, MScA, PhD: Self-heating Can Induce Solid Tumor Necrosis
Denis Rancourt Peng, MScA, PhD Professor Department of Mechanical Engineering Sherbrooke University Quebec City, Canada Abstract Solid tumors are complex biological systems that have been barely studied from a biomechanical point of view. Literature suggests that tumors produce significant heat.…
Ali Uneri, PhD: Image-Guided Robotics: Closing the Loop in Surgical Robotics Using Interventional Imaging
Ali Uneri, PhD Research Associate, Department of Biomedical Engineering Co-Director, Carnegie Center for Surgical Innovation Johns Hopkins University Abstract Intraoperative imaging provides in situ, real time information on the progress of the surgery and location of surgical devices. When paired…
Gabor Fichtinger, DrUniv: Point-of-care-ultrasound Guided Therapies and Interventions in the Global Health Context
Gabor Fichtinger, Dr.Univ. Professor and Canada Research Chair in Computer-Integrated Surgery Queen’s University Kingston, Ontario, Canada Abstract Point-of-care-ultrasound guided therapies and interventions, shortly POCUS-IGT, enables treatment at the bedside, whether in an urban hospital, rural clinic, or mobile care unit. The potential…
Anthony Samir, MD: An Introduction to AI-GUIDE
Anthony Samir, MD Assistant Professor of Radiology Service Chief, Body Ultrasound MGH, Director, MGH Center for Ultrasound Research & Translation Massachusetts General Hospital Harvard Medical School Abstract In this talk, Dr. Samir will introduce the concept of combining machine learning algorithms…
Anand Kumar, PhD: Fluorescence Lifetime Imaging: Applications in Preclinical Research, Clinical Diagnosis and Surgical Guidance
Anand Kumar, PhD Assistant Professor of Radiology Department of Radiology Massachusetts General Hospital Harvard Medical School Abstract My talk will focus on our efforts towards applying fluorescence lifetime imaging in preclinical to clinical settings. I will discuss challenges facing the measurement…
Fan Zhang, PhD: Computational Diffusion MRI Analysis Using Deep Learning
Fan Zhang, PhD Instructor in Radiology Department of Radiology Brigham and Women's Hospital Harvard Medical School Abstract Diffusion MRI is an advanced imaging technique that measures the random molecular motion or diffusion of water molecules. It enables estimation of the underlying…
Aaron Sodickson, MD, PhD and Raphael Cohen: Jump-Starting AI Research in Emergency Radiology: Challenges and Solutions
Aaron Sodickson, MD, PhD Division Chief, Emergency Radiology, Brigham and Women’s Hospital Associate Professor of Radiology, Harvard Medical School Raphael Cohen Senior Machine Learning Scientist, Emergency Radiology and Anesthesiology, Perioperative and Pain Medicine Aaron Sodickson, MD, PhD, FASER is Associate Professor of Radiology…
Guigen Liu, PhD: Development of a Two-Photon Microimaging-Microdevice System for Four-Dimensional Imaging of Drug Delivery in Vivo
Guigen Liu, PhD Instructor in Radiology Department of Radiology Brigham and Women's Hospital Harvard Medical School Abstract Individualized treatment of cancers and many other complex diseases is still a challenge because of the lack of clinically reliable information that uncovers the…
Holden Wu, PhD: Computer-Aided and Robotic Methods for MRI-Guided Percutaneous Interventions
Holden Wu, PhD Associate Professor of Radiological Sciences and Bioengineering Department of Radiological Sciences David Geffen School of Medicine University of California, Los Angeles Abstract Magnetic resonance imaging (MRI) has unique advantages for guiding percutaneous interventions, including exquisite soft-tissue contrast,…
Kishore Rajendran, PhD: Photon-counting-detector CT: Fundamentals, Technical Evaluation, and Clinical Applications
Kishore Rajendran, PhD Associate Consultant, Radiology Research Assistant Professor of Radiology CT Clinical Innovation Center Mayo Clinic Rochester, MN Abstract Photon-counting-detector (PCD) CT system has been recently introduced for clinical use. In this talk, the fundamental detection mechanism of PCDs…
Michael Jerosch-Herold, PhD: Myocardial Tissue Characterization by Magnetic Resonance T1 Mapping
Michael Jerosch-Herold, PhD Director of Cardiac Imaging Physics Brigham and Women's Hospital Associate Professor of Radiology Harvard Medical School Abstract Myocardial T1 mapping provides novel biomarkers of adverse myocardial tissue remodeling that have proven valuable for risk stratification. Most applications…
Sharmila Dorbala, MD, MPH: Molecular Imaging of Light Chain Cardiac Amyloidosis
Sharmila Dorbala, MD, MPH Director of Nuclear Cardiology Brigham and Women's Hospital Professor of Radiology Harvard Medical School Abstract Systemic amyloidoses are heterogeneous group of protein misfolding disorders where misfiled proteins form amyloid fibrils which deposit in the various organs…
Robert Mulkern, PhD: A T2 Trajectory – with and without Ferenc
Robert Mulkern, PhD Associate Professor of Radiology Department of Radiology Boston Children's Hospital Harvard Medical School Abstract The Brigham was a hot bed of magnetic resonance activity in the 1980’s with proton relaxation measurements of tissues playing an important role…
Sanghoon Kim, MD: Introduction to 7T MR Sodium Imaging at BWH
Sanghoon Kim, MD Research Fellow (T32) Department of Radiology Brigham and Women’s Hospital Harvard Medical School Abstract Sodium is one of the essential components of in-vivo cellular homeostasis. This implies that small concentration changes due to various disease processes can…
Viviany R. Taqueti, MD, MPH: Quantitative PET-CT Imaging for Diagnosis and Management of Ischemic Heart Disease and Coronary Microvascular Dysfunction
Viviany R. Taqueti, MD, MPH Director, Cardiac Stress Laboratory Assistant Professor of Radiology Brigham and Women’s Hospital Harvard Medical School Abstract Conventional approaches to diagnostic testing in stable ischemic heart disease (IHD), designed primarily for the identification of obstructive coronary…
Bharti Khurana, MD: Making the “Invisible” Visible: Transforming the detection of Intimate Partner Violence
Bharti Khurana, MD Associate Professor of Radiology Department of Radiology Brigham and Women’s Hospital Harvard Medical School Director, Trauma Imaging Research and Innovation Center Abstract Early diagnosis of Intimate Partner Violence (IPV) represents a critical unmet medical and social need.…
Pietro Nardelli, PhD: Deep Learning for Pulmonary Vascular Disease
Pietro Nardelli, PhD Instructor in Radiology Department of Radiology Brigham and Women’s Hospital Harvard Medical School Abstract Pulmonary vascular disease (PVD) is a term used to indicate any condition that affects the blood vessels along the route between the heart…
Haoyin Zhou, PhD: Laparoscopy Video-based Trackerless Surgical Navigation for Minimally Invasive Liver Surgery
Haoyin Zhou, PhD Instructor in Radiology Department of Radiology Brigham and Women’s Hospital Harvard Medical School Abstract Minimally invasive liver surgery (MILS) is the preferred treatment for liver tumors compared to traditional open surgery due to low blood loss, less…
Andriy Fedorov, PhD: NCI Imaging Data Commons
Andriy Fedorov, PhD Associate Professor of Radiology Department of Radiology Brigham and Women’s Hospital Harvard Medical School Abstract National Cancer Institute (NCI) Cancer Research Data Commons (CRDC) (https://datacommons.cancer.gov/) aims to establish a national cloud-based data science infrastructure. Imaging Data Commons…
Paul B. Shyn, MD: PET/CT-Guided Tumor Ablation: Myths and Promises
Paul B. Shyn, MD Associate Professor of Radiology Department of Radiology Brigham and Women's Hospital Harvard Medical School Abstract Clinical PET/CT was a disruptive technology that blended molecular imaging with anatomic imaging and led to astounding results. The adoption of…
Assaf Tal, PhD: From Function to Cognition: New Spectroscopic Tools for Studying Brain Neurochemistry In-Vivo
Assaf Tal, PhD Assistant Professor Department of Chemical and Biological Physics Weizmann Institute of Science, Israel Abstract In this seminar, I will present new methods in magnetic resonance spectroscopy (MRS) we've been working on in the lab. The talk will…
Robert C. Gentleman, PhD: The Importance of Software and Data (A View of the Future)
Robert C. Gentleman, PhD Executive Director, Center for Computational Biomedicine Harvard Medical School Abstract I will discuss why I believe we are coming to an important inflection where it is important to carefully curate and integrate data resources and to…
Gonzalo Vegas Sanchez-Ferrero, PhD: Harmonization of CT Scans: Reducing Confounding Factors in Multicenter Clinical Studies
Gonzalo Vegas Sanchez-Ferrero, PhD Instructor in Radiology Department of Radiology Brigham and Women’s Hospital Harvard Medical School Abstract Quantitative analysis of CT images in multicenter studies involves dealing with intrinsic disparities in the density measures due to differences in the…
Sughra Raza, MD & Lisa Becker, PhD: From Mammography to Tumor Metabolism
Sughra Raza, MD Associate Professor of Radiology Harvard medical School Lisa Becker, PhD Postdoctoral Fellow VIB-KU Leuven, Belgium Short Bio: Sughra is currently Associate Professor of Radiology at HMS and has worked as a breast imaging radiologist at Brigham &…
Marco Palombo, PhD: Relaxed-VERDICT: Decoupling Relaxation and Diffusion for Comprehensive Microstructure Characterisation of Prostate Cancer
Marco Palombo, PhD UKRI Future Leaders Fellow Centre for Medical Image Computing Department of Computer Science University College London Abstract Prostate cancer (PCa) diagnosis requires transrectal biopsy, which is invasive and prone to error. VERDICT [1,2] is a non-invasive imaging…
Leah H. Portnow, MD: Breast Density: A Continuing Conundrum
Leah H. Portnow, MD Instructor in Radiology Breast Imaging Division Brigham and Women's Hospital Harvard Medical School Abstract In a retrospective review of 200 screening full field digital mammograms, the effect of BI-RADS® 5th edition (5th-ed) guidelines on inter- and…
Lauren O’Donnell, PhD: Novel Analyses of Diffusion MRI Fiber Tractography to Study the Brain’s Connections in Health and Disease
Lauren Jean O'Donnell, PhD Associate Professor in Radiology Brigham and Women's Hospital Harvard Medical School Abstract Our recent research demonstrates that white matter fiber tracts can be automatically identified from diffusion MRI tractography across the lifespan. This enables novel analyses…
Katherine Breedlove, PhD: The Injury-System Paradigm and the Essential Role of Neuroimaging in Concussion
Katherine Breedlove, PhD Research Associate in Radiology Brigham and Women's Hospital Harvard Medical School Abstract Mild traumatic brain injury (mTBI) has proven to be a challenging injury to study. It presents with a complex set of symptoms, highly individualized and dependent…
Ron Kikinis, MD: AI in Medicine: A Technology with Staying Power
Ron Kikinis, MD B. Leonard Holman Professor of Radiology Harvard Medical School Founding Director, Surgical Planning Laboratory Vice-Chair for Biomedical Informatics Research Department of Radiology Brigham and Women’s Hospital Abstract Artificial Intelligence is a technology inspired by biology which is…
Raúl San José Estépar, PhD: Enabling Clinical and Genetic Investigations via Quantitative Imaging in Chronic Obstructive Pulmonary Disease
Raúl San José Estépar, PhD Lead Scientist, Brigham and Women's Hospital Associate Professor of Radiology, Harvard Medical School Abstract Chronic Obstructive Pulmonary Disease (COPD) is a chronic, inflammatory lung disease that arises from exposure to cigarette smoke and other inhaled…
Sarah Frisken, PhD: Modeling the Feeding and Draining Vessels of Cerebral Arteriovenous Malformations
Sarah Frisken, PhD Assistant Professor Harvard Medical School Department of Radiology, Brigham and Women’s Hospital Abstract In this talk, I will present preliminary results for our new efforts to generate patient-specific models of cerebral blood vessels for planning surgical treatment…
Louise M. Clark, PhD: Computer Engineering and 3D Printing an Automated Raman Theranostic Robot
Louise Clark, PhD Postdoctoral Research Fellow Dana Farber Cancer Institute Harvard Medical School Abstract In the treatment of most solid tumors, surgical excision of the gross and microscopic cancer cells is an integral part of the therapeutic pathway. Determining the…
Pedro Moreira, PhD: Towards Data-driven MRI-guided Prostate Interventions
Pedro Moreira, PhD Research fellow in Radiology Brigham and Women's Hospital, Harvard Medical School Abstract Prostate cancer (PCa) is the most common cancer in men, with more than 170,000 estimated new cases in the US yearly. Magnetic Resonance Imaging (MRI) of…
Eduardo Coello, PhD and Alex Lin, PhD: Ultra-High Field MR Spectroscopy: Breaking the Spatio-Temporal Limits
Abstract Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) at ultra-high field (≥7T) benefit from improved signal-to-noise ratio (SNR) and spectral dispersion. This enables potential clinical applications that involve the reliable measurement of low-concentration metabolites with high sensitivity, spatial and…
Gregory DePrisco, MD: Imaging of Uterine Transplants Donors & Recipients
Gregory DePrisco, MD Diagnostic Radiologist Center for Diagnostic Imaging (CDI), Texas Abstract Uterus transplantation is emerging as a treatment for absolute uterine factor infertility. The selection process of donors and recipients is vital to a transplant program's success, particularly as regards live…
Jeffrey Duryea, PhD: The MRI Osteoarthritis Software Score (MOSS): A Quantitative Method to Assess Knee Osteoarthritis
Jeffrey Duryea, PhD Associate Professor, Harvard Medical School Research Faculty Member, Department of Radiology, Brigham and Women's Hospital Abstract Radiological imaging is a proven technology for assessing structural changes produced by knee osteoarthritis (KOA). Conventional radiography is limited since it cannot…
Moritz Kircher, MD, PhD: SERRS Nanoparticles for High Precision Cancer Imaging and Therapy
Moritz Kircher, MD, PhD Chairman, Department of Imaging Dana-Farber Cancer Institute Abstract The detection of cancer at its earliest stage and the accurate delineation of the actual extent of cancer are paramount to achieving better results in cancer treatments. We…
Ross I. Berbeco, PhD: Novel Flat-panel Detector Development for Low Dose MV-CBCT
Ross I. Berbeco, PhD Director of Medical Physics Research Department of Radiation Oncology Brigham and Women's Hospital Associate Professor Harvard Medical School Abstract Using the radiation therapy (MV) beam for imaging has many clinical advantages but is limited by poor…