Guidance Project

Noby hataJayender JagadeesanEhud Scmidt
Nobuhiko Hata, PhD
Core Lead
Jayender Jagadeesan, PhD
Project Lead
Ehud Schmidt, PhD
Project Lead

The long-term goal of Guidance Core is to provide novel guidance methods to improve the outcome of therapies of dynamically deforming and moving organs. This involves developing unique tissue-embedded wireless electromagnetic sensors (EM) and MR-tracked catheters to verify their feasibility and impact on the clinical procedures performed at the Advanced Multimodality Image Guided Operating Room (AMIGO). Projects within this Core are:

Integrated navigation system to accurately localize the tumor and guide the surgical instrument to the optimal resection margin in presence of significant tissue deformation.  We are developing hardware for the integrated navigation system to enable real-time tumor and instrument tracking; a tumor deformation model to estimate the tumor position and optimal resection margin; software for the integrated navigation system to visualize the tumor and surgical instrument. We continue to validate the design and performance of the integrated navigation system in ex-vivo phantoms and in human clinical trials. (Contact: Jayender Jagadeesan)

Verify the ability of active MRI-tracked metallic interventional devices to improve interventions through improved positional accuracy and improved therapy delivery. We are developing a miniature MRI tracking coil array embedded in flexible and rigid metallic stylets and catheters and improving dedicated MR-tracking pulse sequences to locate the devices so as to rapidly and accurately guide insertion of these devices in soft tissue and to monitor the non-rigid deformation of the target tissues. This is expected to enable clinicians to correct the access path based on these data. In addition, motional data provided by the devices is expected to aid in motion-compensated oxygenation imaging for radiation-dose augmentation to hypoxic tumor segments that resist radiation therapy. (Contact: Ehud Schmidt)


Select Recent Publications

  1. Jayender J., Lee T.C., Ruan D.T. Real-Time Localization of Parathyroid Adenoma during Parathyroidectomy. N Engl J Med. 2015 Jul 2;373(1):96-8. PMID: 26132962. PMC4594796.
  2. Schmidt E.J., Watkins R.D., Zviman M.M., Guttman M.A., Wang W., Halperin H.A. A Magnetic Resonance Imaging–Conditional External Cardiac De brillator for Resuscitation Within the Magnetic Resonance Imaging Scanner Bore. Circ Cardiovasc Imaging. 2016 Oct;9(10). PMID: 27729363. PMC5079441.

Full Publication List

Peer-reviewed publications on our research can be found in the NIH/NLM database of biomedical literature by clicking here.

In addition, abstracts presented at national and international meetings are available online here.


Collaborations are a key component of our research program; We closely interact with researchers within our institution, across the US, and internationally. Active collaborations on funded projects are tabulated below, along with resultant publications.


Evaluating Mass Spectrometry for Intraoperative Tissue Characterization in Breast-Conserving Therapy

Collaborating Investigators:  Nathalie Agar, PhD, Mehra Golshan, MD
Collaborating Institution:  Brigham & Women's Hospital, Boston, MA
Grant Number: R01CA201469
Grant Period: 01/06/2015-11/30/2020
NCIGT Projects: Neurosurgery, Guidance
Joint Publications

OpenIGTLink: A Network Communication Interface For Closed-Loop Image-Guided Interventions

Collaborating Investigator:  Junichi Tokuda, PhD
Collaborating Institution:  Brigham & Women's Hospital, Boston, MA
Grant Number: R01EB020667
Grant Period: 07/01/2015-06/30/2018
NCIGT Projects: Guidance, Prostate, Computation, Neurosurgery
Joint Publications


Squamous Cell Carcinoma of the Lung: Validation of Molecular Signatures for Prognosis

Collaborating Investigators:  Fred R. Hirsch, MD, PhD, Raphael Bueno, MD
Collaborating Institutions:  University of Colorado, Denver, Brigham & Women's Hospital, Boston, MA
Grant Number: U01CA157715
Grant Period: 07/09/2012-06/30/2017
NCIGT Team and Project: Jayender Jagadeesan, Guidance
Joint Publications

Software and Documentation