Professor of Radiology, Harvard Medical School
I am a radiologist with significant clinical expertise in imaging in oncology, mentoring fellows and extensive research interest and experience in quantitative MR imaging of prostate cancer. To this end, I have optimized sequences for quantitative analysis of the prostate, specifically dynamic contrast enhanced imaging, which are now part of standard clinical prostate MRI at Brigham and Women’s Hospital. I am currently investigating methods of quantifying prostate tumor response to therapy with MRI, and evaluating these methodologies as a biomarker and guide for treatment approaches for intermediate and highrisk prostate cancer. I have been Principal Investigator on a number of projects specific to optimization of prostate MR for quantitative imaging, including NIH U01 award (U01CA151261) (2010-2015) for “Quantitative MRI of Prostate Cancer as a Biomarker and Guide for Treatment”. My research leverages the National Center for Image Guided Therapy (NCIGT) at Brigham and Women’s Hospital, and the U24 Quantitative Image Informatics for Cancer Research (QIICR) project, both of whom I serve as co-investigator, and the NCI Quantitative Imaging Network (QIN). I have co-authored numerous papers using MRI to assess prostate cancer, including evaluating the repeatability of quantitative MRI indices (ADC and DCE), in evaluating the optimal histopathology correlative processes for prostate MR validation, and more recently in determining the role of quantitative indices over standard PIRADS v2 assessment of prostate cancer. I am an investigator in the Imaging Cancer Heterogeneity TRD of NCIGT.