Oliver Jonas, PhD
I am Director of the Laboratory for Bio-Micro-Devices and Assistant Professor in the Department of Radiology at Harvard Medical School, with appointments at Dana-Farber Cancer Institute and the Broad Institute.
My laboratory focuses on engineering approaches to precision medicine in cancer and other diseases. I develop novel technologies that enable the interrogation of disease in a more rapid, local and precise manner. In addition to seeking clinical impact, I also aim to apply the technologies to generate fundamental new insights into biology, with a particular focus on drug resistance, an area in which I have published several original articles.
I have developed the first generation of the microdevice technology for high-throughput in vivo drug sensitivity testing from an initial idea through all phases of preclinical testing and validation, and into a first clinical pilot study in triple-negative breast cancer which commenced in 2016. My research spanned ideation, concept-to-prototype development, in-vivo testing including extensive animal work and cutting-edge microscopy and optics. Throughout this process, I have interacted extensively with basic scientists and physicians to advance the translational impact of the microdevice technology. My recent projects have integrated the microdevice work with various optical imaging modalities and other analytical methods to combine local perturbations within native tissue with metabolomic, transcriptomic and genomic analysis. My group has extensive experience working with various animal models and we have published several microdevice studies in this area.
I am an investigator in the Guidance TR&D in NCIGT.