Rapid MALDI Mass Spectrometry Imaging for Surgical Pathology

Citation:

Sankha S Basu, Michael S Regan, Elizabeth C Randall, Walid M Abdelmoula, Amanda R Clark, Begoña Gimenez-Cassina Lopez, Dale S Cornett, Andreas Haase, Sandro Santagata, and Nathalie YR Agar. 2019. “Rapid MALDI Mass Spectrometry Imaging for Surgical Pathology.” NPJ Precis Oncol, 3, Pp. 17. Copy at http://www.tinyurl.com/y6gcf7mb

Abstract:

Matrix assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) is an emerging analytical technique, which generates spatially resolved proteomic and metabolomic images from tissue specimens. Conventional MALDI MSI processing and data acquisition can take over 30 min, limiting its clinical utility for intraoperative diagnostics. We present a rapid MALDI MSI method, completed under 5 min, including sample preparation and analysis, providing a workflow compatible with the clinical frozen section procedure.
Last updated on 07/18/2019